2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Adrenergic Receptor

Adrenergic Receptor

Beta Receptor

Adrenergic Receptor

Related Products

PDF 5.98 MB

Adrenergic receptors are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine and epinephrine. Many cells possess these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system. The sympathetic nervous system is responsible for the fight-or-flight response, which includes widening the pupils of the eye, mobilizing energy, and diverting blood flow from non-essential organs to skeletal muscle. There are two main groups of adrenergic receptors, α and β, with several subtypes. α receptors have the subtypes α1 and α2. β receptors have the subtypes β1, β2 and β3. All three are linked to Gs proteins, which in turn are linked to adenylate cyclase. Agonist binding thus causes a rise in the intracellular concentration of the second messenger cAMP. Downstream effectors of cAMP include cAMP-dependent protein kinase (PKA), which mediates some of the intracellular events following hormone binding.

Adrenergic Receptor Isoform Specific Products:

Adrenergic Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0194AS
    Tizanidine-d4 hydrochloride
    		Agonist
    Tizanidine-d4 (hydrochloride) is deuterium labeled Tizanidine (hydrochloride).
    Tizanidine-d<sub>4</sub> hydrochloride
  • HY-N1919R
    Ajmalicine (Standard)
    		Inhibitor
    Ajmalicine (Standard) is the analytical standard of Ajmalicine. This product is intended for research and analytical applications. Ajmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity.
    Ajmalicine (Standard)
  • HY-17416AS
    Guanfacine-13C,15N3
    Guanfacine-13C,15N3 is the 13C and 15N labeled Guanfacine[1]. Guanfacine is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD)[2][3][4].
    Guanfacine-<sup>13</sup>C,<sup>15</sup>N<sub>3</sub>
  • HY-A0019BS
    (R)-9-Hydroxy Risperidone-d4
    (R)-9-Hydroxy Risperidone-d4 is the deuterium labeled (R)-9-Hydroxy Risperidone[1].
    (R)-9-Hydroxy Risperidone-d<sub>4</sub>
  • HY-B1675AR
    Levalbuterol hydrochloride (Standard)
    		Agonist
    Levalbuterol (hydrochloride) (Standard) is the analytical standard of Levalbuterol (hydrochloride). This product is intended for research and analytical applications. Levalbuterol ((R)-Albuterol) hydrochloride is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol hydrochloride is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD.
    Levalbuterol hydrochloride (Standard)
  • HY-15378
    Talibegron hydrochloride
    		Agonist
    Talibegron hydrochloride (ZD2079 hydrochloride) is a potent β3-adrenoceptor agonist with a pD2 of 3.72 on phenylephrine-preconstricted rat mesenteric artery. Talibegron hydrochloride has potent vasorelaxant effect.
    Talibegron hydrochloride
  • HY-116379
    RS-100329
    		Antagonist
    RS-100329 is an α1-adrenergic receptor (α1-AR) antagonist that effectively inhibits α1-adrenergic receptor-mediated contractions of lower urinary tract tissues in vitro and in vivo. RS-100329 can be used in the research of symptoms related to benign prostatic hyperplasia.
    RS-100329
  • HY-122272S2
    Paroxetine-d6-1
    		Inhibitor
    Paroxetine-d6-1 is a deuterated labeled Paroxetine. Paroxetine, a phenylpiperidine derivative, is a potent and selective serotonin reuptake inhibitor (SSRI). Paroxetine is a very weak inhibitor of norepinephrine (NE) uptake but it is still more potent at this site than the other SSRIs.
    Paroxetine-d<sub>6</sub>-1
  • HY-W909149
    TAAR1 agonist 3
    		Agonist
    TAAR1 agonist 3 is a trace amine-associated receptor 1 (TAAR1) agonist (pEC50=7.6). TAAR1 agonist 3 is also a full agonist of the α2A receptor (pEC50=6). TAAR1 agonist 3 can be used in the study of neuropsychiatric diseases.
    TAAR1 agonist 3
  • HY-B0192S2
    Alfuzosin-d3
    		Antagonist
    Alfuzosin-d3 is deuterium labeled Alfuzosin.
    Alfuzosin-d<sub>3</sub>
  • HY-121166
    Levobetaxolol
    		Antagonist
    Levobetaxolol is a potent and high affinity β-adrenergic antagonist with IC50 values of 33.2, 2970, 709 nM for guinea pig atrial β1, tracheal β2 and rat colonic β3 receptors, respectively. Levobetaxolol reduces IOP (intraocular pressure). Levobetaxolol exhibits a micromolar affinity for L-type Ca21-channels. Levobetaxolol decreases the effects of ischaemia/reperfusion injury in rats. Levobetaxolol has the potential for the research of glaucoma.
    Levobetaxolol
  • HY-101337A
    Imiloxan hydrochloride
    		Antagonist
    Imiloxan hydrochloride is a potent and selective alpha 2B-adrenoceptor antagonist. Imiloxan hydrochloride has the potential for acute kidney injury research.
    Imiloxan hydrochloride
  • HY-B0010AS
    Formoterol-d3
    		Agonist
    Formoterol-d3 is deuterium labeled Arformoterol. Arformoterol ((R,R)-Formoterol), the (R,R)-enantiomer of Formoterol, is a long-acting β2-adrenergic receptor (β2-AR) agonist, with a Kd of 2.9 nM. Arformoterol can be used for the research of chronic obstructive pulmonary disease (COPD)[1][2].
    Formoterol-d<sub>3</sub>
  • HY-B1001
    Todralazine
    		Inhibitor
    Todralazine (Ecarazine) is an anti-hypertensive agent, acts as a β2AR blocker, with antioxidant and free radical scavenging activity.
    Todralazine
  • HY-106361
    Flerobuterol
    		Agonist
    Flerobuterol is a beta-adrenoceptor agonist with antidepressant activity. Flerobuterol enhances serotonergic neurotransmission.
    Flerobuterol
  • HY-A0077AS
    Perphenazine-d8 dihydrochloride
    		Inhibitor ≥98.0%
    Perphenazine-d8 (dihydrochloride) is the deuterium labeled Perphenazine, which is a typical antipsychotic agent(5-HT, Dopamine receptor ligand).
    Perphenazine-d<sub>8</sub> dihydrochloride
  • HY-116771
    CL 316243 free acid
    		Agonist 99.37%
    CL316243 free acid is a highly potent selective β3-adrenoceptor agonist with a EC50 of 3 nM, but is an extremely poor to β1/2- receptors. CL316243 free acid is a effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate. CL316243 free acid has the potential for the treatment obesity, diabetes and urge urinary incontinence.
    CL 316243 free acid
  • HY-B0362AR
    Phentolamine mesylate (Standard)
    		Antagonist
    Phentolamine (mesylate) (Standard) is the analytical standard of Phentolamine (mesylate). This product is intended for research and analytical applications. Phentolamine mesylate (Phentolamine methanesulfonate) is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine mesylate can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction.
    Phentolamine mesylate (Standard)
  • HY-B0409AR
    Clonidine hydrochloride (Standard)
    		Agonist
    Clonidine (hydrochloride) (Standard) is the analytical standard of Clonidine (hydrochloride). This product is intended for research and analytical applications. Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent.
    Clonidine hydrochloride (Standard)
  • HY-103093R
    Zotepine (Standard)
    		Antagonist
    Zotepine (Standard) is the analytical standard of Zotepine. This product is intended for research and analytical applications. Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM and 8 nM, respectively. Zotepine exhibits antidepressive and anxiolytic effects in vivo.
    Zotepine (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
Adrenergic Receptor Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.